The growing number of peroral endoscopies necessitates the perfection of a convenient method of anesthesia or analgesia particularly suitable for these procedures. Intravenous thiopental (Pentothal) in combination with one of the muscle-relaxing agents is one of the best methods available. However, this combination necessitates the services of an experienced anesthetist and requires hospitalization of the patient. On the other hand, the usual local anesthesia alone, although sufficiently analgetic locally, frequently renders the examination very inconvenient for the patient. It is on account of these difficulties that physicians often hesitate to refer their patients for endoscopy as a routine procedure, especially in the case of non-hospitalized patients.
Ideally, the successful performance of endoscopies requires a general analgetic drug whose effect is of short duration, producing adequate muscle relaxation which at the same time leaves the patient sufficiently awake in order to cooperate, and which also has a wide margin of safety
ALTMAN MM, FIALKOV G. The Use of Meperidine in Peroral Endoscopies. AMA Arch Otolaryngol. 1957;65(3):221–224. doi:10.1001/archotol.1957.03830210019004
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