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March 1957

Malignant Granuloma of the FaceContribution to Its Nosology

Author Affiliations

Sao Paulo, Brazil
From the Departments of Pathology (Dr. de Faria), Otolaryngology (Dr. Cutin and Dr. Morgante), and Bacteriology and Immunology (Mr. Ferri), University of Sao Paulo, Faculty of Medicine.

AMA Arch Otolaryngol. 1957;65(3):255-262. doi:10.1001/archotol.1957.03830210053008

Since McBride18 reported, in 1896, the first case of malignant granuloma, only scattered observations have been published in several countries. Gottesberge,14 however, presented seven cases. A review of the literature was done recently by Terracol32 (1954), who called attention to the abundant synonimia, mentioning nasal malignant granuloma, granuloma gangraenescens, sarco lupo pernio, nasal and facial mutilating mortal granuloma, mortal progressive granulomatous ulceration of the nose, gangrenous osteomyelitis of the paranasal sinus, nasal chronic infectious granuloma of unknown cause, idiopathic granuloma of the facial medial tissues, facial mycosis fungoides, pseudotumoral inflammation, malignant reticulosis, malignant mesenchymoma of the nasal-maxillary region, etc. The entity is more frequent in adult males and rare in children.

The most characteristic feature of the disease is the ulcerous-necrotic process, progressing inexorably and resisting any therapeutic measures, as it has been observed in the majority of the cases studied. Its features were described by Stewart

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