In 1949, when several antibiotics were available for the treatment of sinorespiratory infections, it was considered advisable to choose the antibiotic for therapy on the basis of cultures and inhibition testing. This was continued for a number of years, so that it became possible to indicate the type of organism(s) encountered in sinorespiratory infections, their yearly variations, and sensitivity to antibiotics with continued use. Thus it was noted that with chronic or recurrent sinorespiratory infections the hemolytic Staphylococcus (Micrococcus pyogenes var. aureus) was frequently encountered, either singly or in combination with other organisms (Panel 1).
During the performance of the inhibition testing it became apparent that bacterial resistance was developing to each of the antibiotics used singly (Panel 2). This was particularly true when confronted with the hemolytic Staphylococcus.1,2 This led us then into experimental studies on the use of combinations of antibiotics and their application clinically (Panels 3
PRIGAL SJ. The Treatment of Sinorespiratory Infections: A Bacteriologic and Epidemiologic Approach. AMA Arch Otolaryngol. 1957;65(5):527–534. doi:10.1001/archotol.1957.03830230103020
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