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August 1957

Observations on the Experimental Use of Radioactive Isotopes Within the Larynx of the Dog: Notes on the Submucosal Compartments of the Human Larynx

Author Affiliations

Los Angeles
From the Departments of Surgery (Division of Head and Neck Surgery) and Radiology, University of California Medical School at Los Angeles.

AMA Arch Otolaryngol. 1957;66(2):150-156. doi:10.1001/archotol.1957.03830260036004

Studies on the local spread of fluids injected into the larynx, carried out as a preliminary investigation to the use of radioisotopes, have revealed interesting anatomical data pertaining to the presence of isolated submucosal laryngeal compartments. These are herein reported.

Whether the use of radioisotopes will be effective in the treatment of laryngeal cancer is not known, but before it is attempted, certain basic facts should be established. These include the direction and degree of spread of fluids injected into a particular site, and the effects of locally injected radioactive isotopes on the normal structures of the larynx. A technique needs to be developed for the injection of the isotopes to assure effective distribution throughout the involved area and to avoid contamination. Determination of the length of time that the radioisotope will remain within the larynx is of particular importance, since up to now it has not been known

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