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September 1957

Adrenal Cortical Influence on Lymphatic Tissue Function

Author Affiliations

Salt Lake City
From the Department of Surgery and Anatomy, University of Utah Medical School, The Memorial Medical Center, and The Holy Cross Hospital.

AMA Arch Otolaryngol. 1957;66(3):245-247. doi:10.1001/archotol.1957.03830270003001

A type of hypogammaglobulinemia is reported in which certain adrenal cortical hormones enhance the release of antibody. Analysis of our 48 cases showed two main types. First, a predominant type found in the hypolymphatic type of person described by Good. Second, a type found in a small number of cases, about 10% of persons with hyperplasia of the lymphoid tissue. The following study attempts to demonstrate that, despite the fact that adrenal cortical hormones are responsible for the inhibition of lymphocyte formation, they may raise the blood level of globulins by clinically significant amounts.

In reviewing the series of hypogammaglobulin cases, we found one report of a mother and a newborn baby, both with marked hypogammaglobulinemia. The child developed pneumonia within the first day of life. The infection did not respond to antibiotics but, on being given gamma globulin, the child recovered promptly. In seeking an explanation of why only