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This is a report on 20 years' investigation of the use of chemicals applied to the skin surface of the body to limit extension of malignancy, and allow for surgical removal. The involved area is controlled by taking microscopic sections and studying them from time to time to determine delimitation. There are thoroughly documented statistics to show five-year results in a large series of cases. This is a method for the microscopically controlled excision of cancer. Each step of treatment is illustrated by photographs and photomicrographs, in color and in black and white. The technique pertains to surface cancer, which can be subjected to chemical fixation in situ, surgically excised, and examined as frozen sections under the microscope. The author stresses unprecedented reliability based on conservatism. However, it is advisable that no one undertake this method by reading only. Bedside and operating-room observation are of paramount importance, plus the actual