"Corticotropin and the related adrenocortico-steroids are the most powerful agents that have come into man's possession since Prometheus stole fire from the gods. But their power can be for evil as well as for good, and we are only beginning to know their possibilities and adapt them to our use." This statement was made before the American Laryngological Association a few years ago by Dr. Richard Kern,1 and its significance should be recognized by all otolaryngologists.
To properly appraise the steroids it might be well to point out briefly the physiologic effects of corticotropin (ACTH). The adrenal cortex in response to stimulation by corticotropin from the anterior pituitary produces at least 28 steroid substances. The outer layer, or zona glomerulosa, produces desoxycorticosterone (DOC) and is concerned with salt and water balance. The inner layer, or zona reticulosa, has to do with gonad function and is the source of estrogen
SILCOX LE. Use of Corticosteroids in Otolaryngology. AMA Arch Otolaryngol. 1957;66(6):710–713. doi:10.1001/archotol.1957.03830300090009
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