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February 1958

The Nature of Senile Changes of the Human Olfactory Bulb and Tract

Author Affiliations

Ann Arbor, Mich.; Detroit
From the Laboratory of Neuropathology, Neuropsychiatric Institute, University of Michigan Hospital, and the Department of Neurosurgery, Henry Ford Hospital, Detroit.

AMA Arch Otolaryngol. 1958;67(2):167-171. doi:10.1001/archotol.1958.00730010173006

The senile changes found in the human olfactory bulb and tract are similar to those found in the central nervous system. These changes are characterized by generalized atrophy, loss of neuronal elements, increase of astroglia, and numerous corpora amylacea. In the present study the nature of these changes was investigated in numerous aged persons and in one case which represented "experiment-like" conditions.

Material and Methods  The olfactory bulbs and tracts used for the present investigation were obtained on routine postmortem examinations from persons of age 70 or more. One olfactory bulb used as a comparison with those of aged persons was obtained on autopsy of a 42-year-old woman who 10 months prior to her death had a hypophysectomy because of bony metastases from breast carcinoma. For the removal of the hypophysis a right frontal craniotomy was performed, and an intradural approach to the pituitary was carried out. The frontal lobe

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