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February 1958

An Explanation of the Pathogenesis, Physiology, and Therapy of Meniere's Disease

AMA Arch Otolaryngol. 1958;67(2):184-196. doi:10.1001/archotol.1958.00730010190010

The search for the singularly most efficient and permanent while least debilitating therapeutic approach in the treatment of Ménière's disease, or hydrops labyrinthi, has concerned investigators ever since Hallpike and Cairns published their findings on this disease in 1938.

The range of therapies runs the gamut from the nonsurgical managements by diet control (Furstenberg, Lashmet, and Lathrop) and vitamin dosage (Selfridge), over the streptomycin (Hanson), nicotinic acid (Atkinson), and histamine (Derlacki, Sheldon and Horton, Shambaugh, Lillie et al.) routes, down the unmarked trails of infected foci (Wright, Kemler), through the intersection of eighth cranial nerve surgery (Crowe, McKenzie, Green and Douglass), along the byways of stellate ganglion injections or dorsal sympathectomy (Passe, Johnson, Strong) and finally, home to the complete or partial obliteration of the labyrinthine apparatus (Cawthorne, Day, Goodyear, Perlman, Portmann).

Conflicting Etiological Beliefs  The wide variations in these therapies can best be attributed to the variations found in