Papilloma of the larynx appearing in childhood is reputed to have a tendency to be self-limited and to undergo spontaneous regression before or during adolescence. In this respect, it is similar to verruca vulgaris. The viral etiology and contagious nature of the common wart were first demonstrated by Jadassohn1 in 1895. Ullmann,2 in 1923, was the first to report similar experiments on the bacteria-free filtrate of macerated papillomatous tissue from the larynx of a child. He produced typical clinical and pathological lesions by inoculating himself and a laboratory assistant with the filtrate. Inoculation with the filtrate from adult papillomatous tissue failed to produce cutaneous lesions. He agreed with Chiari that juvenile and adult papilloma are clinically different diseases.
The precise effect that puberty exerts in the course of juvenile papilloma has never been defined, and it would seem that the theory itself, which has been recently challenged by
JESBERG N. Papilloma of the Larynx: A Case of Protracted Duration, 1878-1955. AMA Arch Otolaryngol. 1958;67(2):222–225. doi:10.1001/archotol.1958.00730010228016
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