Papilloma of the larynx remains one of the most vexing problems facing laryngologists today. At present, the best that can be offered a papilloma patient is judicious surgical removal and the topical application of podophyllin. In those with minimal disease this procedure may result in a cure, but more often, particularly when the disease is extensive, years of laryngeal obstruction and dysphonia are to be expected. Occasionally the papillomata are implanted in the bronchi, and the prognosis becomes even more serious. More must be known about the etiology of laryngeal papilloma before the problem of therapy can be intelligently approached.
Virologists generally agree that the various papillomata which plague mankind are caused by similar, if not by identical viruses. Von Rooyen1 categorized them as follows: Common gray firm warts, small flat juvenile warts, pedunculated digitate types, delicate filiform warts, genital papilloma, and papilloma of the larynx. Patients having several
PINSKER OT, PROUD GO. Studies on the Etiology of Papilloma of the Larynx: Progress Report. AMA Arch Otolaryngol. 1958;67(3):268–270. doi:10.1001/archotol.1958.00730010276002
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