James Paget was the first to draw attention to mixed tumors outside of the major salivary glands, in 1851. Since this time, mixed tumors have been reported to arise from numerous areas: eyebrow, cheek, pharyngeal wall, tongue, and even in distant areas such as the leg and the hand, but these are most exceptional sites of origin.
Outside the major salivary glands, they are, by far, commoner in the upper respiratory tree; Hayes Martin has stated that "the palate is the site of origin of a greater percentage of benign mixed tumors of the salivary gland type, than any other structure of the head and neck, except the parotid salivary gland." Cordray reported that in 61 cases of mixed tumors seen during a period of 10 years, at the tumor clinic of the Massachusetts Eye and Ear Infirmary, 7 were in the palate. Owens, reviewing the literature over a period
MONTREUIL F. Mixed Tumors of the Palate. AMA Arch Otolaryngol. 1958;67(3):313–318. doi:10.1001/archotol.1958.00730010321007
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