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Case Report/Case Series
May 1958

Rhinomucormycosis Resulting in Fatal Cerebral Mucormycosis

Author Affiliations

Norwalk, Conn.; Burlington, Iowa
From the Departments of Otolaryngology and Pathology, Norwalk Hospital.; Assistant Clinical Professor, Department of Otolaryngology, Yale University School of Medicine (Dr. Dwyer). Present address of Dr. Changus: Director of Laboratories, Mercy Hospital, Burlington, Iowa.

AMA Arch Otolaryngol. 1958;67(5):619-623. doi:10.1001/archotol.1958.00730010633022
Abstract

The early identification of the primitive class of fungi, the Phycomycetes, in the biopsy and culture of the nasal and paranasal lesions of two diabetic patients led to the control of the spread of the fungi into the brain, where fatal cerebral mucormycosis might have resulted (Harris1; Baker, Andrews and Izlar2). The fungi of the genus Rhizopus of the order Mucorales were identified in both patients. Fifteen of the seventeen recorded cases, including the present case, died as a result of the spread of the fungi into the brain (Table). Earlier recognition through biopsy or culture of the nasal or paranasal lesions may have averted cerebral spread and death.

All of the reported cases had an underlying, debilitating disease. Uncontrolled or poorly controlled diabetes mellitus1-7 provided a favorable medium of growth of the fungi in 11 of the 17 recorded cases, including the present case. The underlying

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