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June 1958

Histoplasmosis Involving the Larynx

Author Affiliations

U. S. Army
Otolaryngology (Capt. King); Internal Medicine (Capt. Cline), Walter Reed Army Hospital, Walter Reed Army Medical Center.

AMA Arch Otolaryngol. 1958;67(6):649-654. doi:10.1001/archotol.1958.00730010665002

In the past decade and a half histoplasmosis has risen from relative obscurity to a prominent place in medical thinking. While almost all the tissues of the body may be affected by this disease, and it has come repeatedly under the eye of the otolaryngologist, only about 20 cases have been reported in which the larynx has been involved. A review of the literature leads one to suspect that laryngeal involvement may be a commoner problem than this small number of cases indicates. A brief review of the disease is accompanied by another case report of a patient with extensive laryngeal involvement.

Histoplasmosis is defined by Roberts1 as a subacute or chronic infection caused by the fungus Histoplasma capsulatum.1 Darling2 first described the disease in 1905, when he discovered the causative organisms in the tissues. Because of their appearance, however, he believed them to be protozoa. They

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