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June 1958

Tissue Reaction to Implants

Author Affiliations

Kansas City, Mo.
From the Department of Otolaryngology, University of Kansas School of Medicine, Kansas City, Kan.

AMA Arch Otolaryngol. 1958;67(6):660-667. doi:10.1001/archotol.1958.00730010676004

Aims and Objectives  This study is presented in the hope that it will be a contribution to knowledge of tissue reaction to the commoner as well as to several uncommon materials used as implants upon the bony nasal dorsum. Dogs were used in this experiment because of their availability and because the relationships among their nasal bones, cartilages, skin, and subcutaneous tissue are reasonably similar to that found in the nasal dorsum of man.

Previous Experimental Work with Grafts in Animals and Humans  Careful search of both the dental and the medical literature reveals animal experimentation in implant materials, but nothing very closely corresponding to this experiment.Searcy, Carmichael, and Wheelock,8 in 1944, implanted the following substances subcutaneously in rats to determine which would be most firmly fixed with fibrous tissue: (a) cotton wool, (b) cotton string, (c) cotton gauze, (d) nylon staple (sized), (e) viscose rayon staple, and

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