In an earlier paper1 I reported the effect of some nose-drop solutions on the ciliary activity in the upper respiratory tract. The clinical significance of decelerated ciliary beating was also discussed. Attention was drawn to the risk of respiratory-tract infection when mucus flow is retarded or arrested. The effect of the solutions on ciliary activity is not the only important factor, however. Their bactericidal properties must also be taken into account.
Similar studies have now been performed with agents which, because of their expectorant effects, are traditionally included in many cough syrups. Ammonium chloride, potassium iodide, sodium citrate, and ipecac fluidextract and senega fluidextract were used in these tests. In recent years agents which more markedly reduce surface tension have also been included in cough mixtures. The study was therefore extended to comprise sodium lauryl sulfate, polyoxyethylene sorbitan monolaurate (Tween 20) and polysorbate 80 (polyoxyethylene sorbitan monooleate, Tween 80).
DALHAMN T. The Influence of Some Expectorants on the Rate of Ciliary Beat in the Trachea of Living Rats. AMA Arch Otolaryngol. 1958;68(1):20–21. doi:10.1001/archotol.1958.00730020024002
Customize your JAMA Network experience by selecting one or more topics from the list below.