In 1822 the famed German pathologist, Friedrich D. von Recklinghausen, first described a condition known as neurofibromatosis, or multiple neurofibromata of the skin. Since that time, the same tumors have been described involving practically all of the visceral nerves. This peculiar and often familial condition usually presents itself as large numbers of tumors, sometimes hundreds, growing from fine cutaneous nerves so that the condition is known as multiple neurofibromata. The skin type forms soft nodules which may be located over the entire body. There are also pigmentations or patches which are not the nodular type and which present themselves as brown spots or freckles, commonly referred to as being "café au lait" spots. The condition may be quite disfiguring to the patient; however, these tumors are usually benign in character. The deeper growths are the most dangerous because of their space-occupying effect and are more prone to undergo sarcomatous change,
LYONS GD, FUCHS VH. Von Recklinghausen's Disease of Nasopharynx. AMA Arch Otolaryngol. 1958;68(1):47–49. doi:https://doi.org/10.1001/archotol.1958.00730020051008
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