Neoplastic diseases which occur in the infratemporal and the pterygopalatine fossae are rare and unusual in their manifestations. During their early phase, tumors in this area may cause symptoms similar to well-known neuralgias. Frequently, the teeth will be extracted or the patient may receive treatment for sinusitis. A diagnosis of Costen's syndrome, Sluder's syndrome, or psychoneurosis may be made before the true nature of the disease is found. At the onset, these tumors do not extend externally beyond the confines of the fossae.
Therefore, they do not present physical findings within the oral cavity, nose or nasopharynx. X-ray examination is usually normal until further growth has occurred.
Tumors which occur in the infratemporal fossa present symptoms that are distinctly different from those which arise in the pterygopalatine fossa or the sinus of Morgagni. In this respect, an interesting differential diagnosis can be made if the anatomy of this area is
STRAND SO. Primary Tumors of the Infratemporal and Pterygopalatine Fossae. AMA Arch Otolaryngol. 1958;68(4):437–450. doi:https://doi.org/10.1001/archotol.1958.00730020455006
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