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December 1958

Secretory Otitis Media and Nasal Allergy: Preliminary Report of Sixty-Six Patients Treated with Promethazine

AMA Arch Otolaryngol. 1958;68(6):748-751. doi:10.1001/archotol.1958.00730020772013

Nasal allergy as a complicating and often confusing accompaniment to diseases of the upper respiratory system has been frequently reported in medical literature. Silbert,1 in stressing the necessity for differential diagnosis of this syndrome, estimates that 75% of the patients he sees exhibit some form of sensitivity; and Gehrand,2 in a clinical study of 134 cases selected for extreme susceptibility to respiratory infections, found well-defined clinical evidence of allergy in 74%.

Promethazine,* a potent and long-acting antihistamine, has proved effective in a wide variety of allergic upper respiratory disorders.3-6 The therapeutic efficiency of this drug, combined with its freedom from undesirable side-effects, suggested a clinical evaluation of promethazine for symptomatic relief of secretory otitis media and nasal allergy concurrent with specific treatment of the underlying condition.

Method  The study comprised 66 patients (61 adults and 5 children) ranging in age from 8 to 73 years, who were

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