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January 1959

Modifications of Cochlear Responses by Oxygen Deprivation

Author Affiliations

From the Division of Otolaryngology of the University of Chicago.

AMA Arch Otolaryngol. 1959;69(1):82-94. doi:10.1001/archotol.1959.00730030086011

Several workers have investigated the susceptibility of cochlear potentials to oxygen deprivation. The results showed that cochlear microphonics, action potentials, and DC resting potential are oxygen-dependent. Békésy1 demonstrated that both cochlear microphonics and DC resting potential, as recorded from scala media, followed the same time-course decay during anoxia. Wever et al.2 reported that in the cat the amplitude of cochlear microphonics diminished when the concentration of oxygen in the respirating gas mixture was below 4%. Lawrence and Wever3 reported a detectable lesion in the organ of Corti of cats exposed to severe oxygen deprivation. However, Falbe-Hansen et al.4 did not find such changes in guinea pigs and cats exposed to either acute or prolonged oxygen lack. Bornschein and Gernandt5 showed that by repeating the exposure to anoxia, the neural components can be removed selectively from cochlear microphonics. But according to other investigations6 this method

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