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May 1959

A Comparative Study of Nasal Decongestion by Sympathomimetic Drugs

Author Affiliations

Philadelphia; Tuckahoe, N. Y.
Departments of Pharmacology, University of Pennsylvania School of Medicine and Wellcome Research Laboratories.

AMA Arch Otolaryngol. 1959;69(5):598-605. doi:10.1001/archotol.1959.00730030610013

The current widespread use of about 15 sympathomimetic drugs to decongest the nasal mucosa has provoked the question of their comparative effects. There are two approaches in obtaining direct evidence for nasal decongestion. In man, there are several methods that have been introduced to measure nasal resistance (see references cited in monograph by Uddstromer,1 1940). Unfortunately, only ephedrine2 and methamphetamine3 have been studied with the benefit of such methods. In 1939, Jackson4 introduced a method using dogs for assessment of nasal congestion and decongestion by closure of the posterior nares with a rubber ball and measuring intranasal pressure from the anterior nares. A reduction in intranasal pressure indicating decongestion has been reported following the intravenous injection of the following drugs: amphetamine, cyclopentamine, epinephrine, ephedrine, mephentermine, methamphetamine, methylaminoheptane, phenylpropanolamine, phenylephrine, p-(2-methylaminopropyl)phenol (Pholedrine), and pseudoephedrine.6-11 There is no information on the ability of eight other currently

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