An acceptable nasal formulation should be considered not only from the standpoint of its desired local therapeutic effects on the nasal sinus and mucous membranes, its possible secondary systemic effects on the body, its nonsensitizing properties, its proper pH and isotonicity, but should also be considered for its effect on ciliary motility.
Batteries of tests have been established in governing the safe administration of drugs through the many routes of injection in man. However, such standards do not seem to be well established for formulations instilled into the nasal cavity. Though minute in structure and primitive biologically, cilia function vigorously even in the presence of infections, allergens, industrial fumes, foreign bodies, and variations in temperature. They are found in some of the nasal sinuses and in the nasal part of the pharynx. They extend from the base of the epiglottis down the larynx, trachea and bronchi and down to the
KIMURA ET. Effects of Chemical Agents on Ciliated Tracheal Epithelium. AMA Arch Otolaryngol. 1959;69(6):674–686. doi:10.1001/archotol.1959.00730030688003
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