Drugs presumed to increase the coagulation of blood or to increase the strength of capillaries are frequently used prior to tonsillectomy or adenoidectomy without indictation that the patient requires or, indeed, benefits from them. The interpretation of results obtained from these agents is necessarily based upon subjective evaluation, since accurate measurement of bleeding during the operative procedure is difficult. The physician tends to be influenced in subjective evaluations by his conception of the anticipated results; no results have been found of a "blind trial" of coagulant agents, in which the surgeon was unaware of whether the drug to be tested or a placebo had been given.
The present report concerns such a "blind trial" of three agents commonly employed to reduce bleeding during tonsillectomy and adenoidectomy. The agents evaluated were (1) a combination of oxalic and malonic acids (Koagamin), (2) adrenochrome monosemicarbazide (Adrenosem) and (3) intravenous estrogens (Premarin).
THAJEB S, KURKCUOGLU M, McELFRESH AE. The Value of Systemic Hemostatic Drugs: A "Double Blind" Evaluation of Agents Used to Increase Coagulation During Tonsillectomy and Adenoidectomy. AMA Arch Otolaryngol. 1959;70(1):72–74. doi:10.1001/archotol.1959.00730040076013
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