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July 1959

Esophagitis Edematosa Circumscripta Chronica: Histological Investigation

Author Affiliations

Yokohama, Japan

AMA Arch Otolaryngol. 1959;70(1):98-102. doi:10.1001/archotol.1959.00730040102016

In 1951, a lesion which should be referred to as esophagitis edematosa circumscripta chronica was reported by us.1 The chief complaint of patients with this lesion is foreign-body sensation at the upper part of the esophagus. Although there are many diseases which produce a similar sensation, this lesion may be considered as the predominant cause of it.

During the past 10 years, we have been carrying out a histopathological study of specimens removed endoscopically in cases with this lesion, and findings observed in 91 cases are as follows:

Esophagoscopically in this lesion, edema, swelling, and sometimes redness of the mucous membrane are observed at 17 to 22 cm. from the upper incisor teeth. Specimens for biopsy were taken for histological examination.

The initial sign of histopathological change observed is congestion of capillaries in the submucous layer of the esophagus. Then, as a result of increased permeability of the capillaries, serous