Ostamer* is a polyurethane foam which has been used successfully as a bonding agent in fractured and diseased bones.1-3 In its presently available form, Ostamer is prepared by mixing together at surgery a prepolymer (prepared by reacting a polyol with an aromatic polyisocyanate) with a catalyst (a mixture of alaphatic tertiary amines and water) in the ratio of 4:1. The resultant mixture is a thick, extremely adhesive substance from which carbon dioxide and heat are liberated. On hardening, it swells to twice the original volume to form a very light porous plastic.
Ostamer produces little or no tissue reaction at the time of application, according to published reports on animals and humans. The oldest human implant was performed three years ago, and as yet no evidence of toxicity has been detected.
In view of the adhesive properties, light weight, and apparent absence of toxicity, the possibility of using Ostamer
SATALOFF J. Repair of Ossicular Defects with Ostamer. AMA Arch Otolaryngol. 1959;70(4):415–418. doi:10.1001/archotol.1959.00730040425001
Customize your JAMA Network experience by selecting one or more topics from the list below.