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October 1959

Experimental Intralaryngeal Injection of Radioisotopes

Author Affiliations

Los Angeles
From the Department of Surgery, Division of Head and Neck Surgery, and the Department of Radiology, University of California at Los Angeles.

AMA Arch Otolaryngol. 1959;70(4):459-465. doi:10.1001/archotol.1959.00730040469007

This report is concerned with the experimental injection of CrP32O4 and Cr51P32O4 (radioactive isotopes) into the submucosal spaces of the larynx. Observations were made of the local effects of the radiation from P32 on the larynx and the distribution of the CrP32O4 within this organ. These observations have expanded our knowledge of the anatomy and physiology of the larynx and have proven helpful in understanding the natural history of certain diseases of the larynx.

The ability of the normal larynx, as a whole, and of its component parts to tolerate injected radioactive material has been observed and the way opened for a clinical trial of radioisotopes in the treatment of certain cancers of the vocal cords. It has likewise been established that if radioisotopes are to be used for the treatment of cancer of the larynx the injection

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