My interest in this subject dates from my military service in the Navy during World War II, at which time all of the medical officers were plagued with patients with external fungous infections of the skin and especially the external ear. I recall, on my first day of duty at the Naval Air Station on the Gulf of Mexico in Texas, when I was presented with 52 cases of otomycosis.Definition.—T.O.E. refers to the combined extract of Trichophytin, Oidiomycetes, and Epidermophyton, which represent the three important groups of pathogenic fungi known to produce allergic symptoms.History.—Mycotic infections are noted for three characteristics: (1) their resistance to treatment, (2) their recurrence, and (3) their complications. Recent research has indicated that the resistance to treatment as well as the recurrences are due to altered sensitivity.1This paper is concerned with the allergic complications of the skin and mucous membrane (or the
BROWN DW. The Clinical Use of T.O.E. in E.E.N.T. Practice. AMA Arch Otolaryngol. 1959;70(5):588–592. doi:10.1001/archotol.1959.00730040600009
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