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January 1960

An Unusual Site of Metastasis from the Larynx

Author Affiliations

Oklahoma City
Department of Otolaryngology, Veterans Administration Hospital, Oklahoma City.

AMA Arch Otolaryngol. 1960;71(1):95-97. doi:10.1001/archotol.1960.03770010099010

The primary purpose of this article is to present an unusual metastatic site of squamous cell carcinoma from the larynx to the endocardium of the right ventricle.

After perusing the great amount of literature on laryngeal carcinoma and its near and distant metastases, I have been unable to find any reference to cardiac involvement.

It is well known that these laryngeal cancer cases have three periods of development; the first stage, or localized state, which usually is associated with hoarseness; the second stage, wherein regional lymphatic invasion occurs, and the third stage of extension to distant organs and tissues, which are not in direct relationship to the original nidus of cancer.

The means by which carcinoma invades adjacent and remote areas is fairly well understood. Briefly, it metastasizes by way of the lymphatic system, by embolic phenomenon, cancerous lymphangitis, and by diversion and reflux of blockaded lymph and other vascular

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