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March 1960

Chairman's Remarks

AMA Arch Otolaryngol. 1960;71(3):581. doi:10.1001/archotol.1960.03770030223033

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Some of the men suggested that I try to simplify Dr. Godlowski's highly scientific explanation of the enzymatic concept of allergy.

Picture a cell with its nucleus. We see here a foreign protein which enters the cell and stimulates the production of a specific enzyme called the adaptive enzyme, produced by the cell for that particular protein. This is a healthy cell of a person who has no inhibition of enzyme production or activity. His hormones are in balance. He has no fever, nor has he taken a coal tar derivative, antibiotic, or other enzyme inhibitor. Therefore, he produces nice, normal adaptive enzyme which proceeds to cause all-ornone proteolysis of the foreign protein, breaking it down into harmless amino acids which are then utilized by the cell to build up its own protein.

Next to this normal cell, imagine the cell of the allergic person. Again, a foreign protein enters the cell, but this time the adaptive enzyme produced by the cell for this particular protein is of an abnormal type—due to either hormonal deficiency in the patient or the action of an enzyme inhibitor. This abnormal adaptive enzyme does not produce all-or-none proteolysis; rather, it produces a partial or piecemeal proteolysis, producing a number of toxic products, including histamine, serotonin, etc. These are the toxic products which

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