Antihistamines have found a definite place in treatment of the symptoms of many allergic reactions. There are a large number of commercial preparations available and a correspondingly large number of clinical reports on each drug. It seems advisable to attempt a comparison of some of the drugs which are clinically established. This is not an easy task. Many of the factors influencing the clinical evaluation of drugs have been emphasized by Modell and Houde.1
A clinician attempting to evaluate antihistamines is faced with special problems. He must attempt to cope with antihistamine tolerance.2 Further, it has been noted that a patient may show no response to one antihistamine, and when an antihistamine of a different chemical structure is employed, a favorable response is obtained.3 The allergic element of the disorder is usually a fluctuating one. For example, the amount of pollen striking the nasal mucus membranes may
GRATER WC. Comparative Effectiveness of Two Antihistamines in Allergic Rhinitis: A Double-Blind Label Study Comparing Parabromdylamine Maleate and Tripelennamine in Various Dosages. AMA Arch Otolaryngol. 1960;72(1):63–65. doi:10.1001/archotol.1960.00740010067011
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