The average incidence of nasopharyngeal carcinoma in large cancer clinics varies between 0.7% and 2.5% of all malignancies reported.1 A well-known exception to this low percentage is the much higher occurrence found in the Chinese where it is more than 30 times as common.2 The incidence of this tumor in children is much more infrequent and makes up only 1% of the total number of cases.3 The unfortunate odds of this disease striking two children in one non-Chinese family is infinitesimally small. There have been two such reports in the literature. One was by McConnell4 and the other by Stinson and Whiteleather.5,6 This article will report the third such occurrence.
Another rare finding of this report is that of hypertrophic osteoarthropathy as a complication of nasopharyngeal carcinoma. In reviewing the literature there is a reference by Martin, a radiologist, in an article published in 1938,
JAFFEE IS. Nasopharyngeal Carcinoma: Unusual Case Reports. Arch Otolaryngol. 1964;80(4):450–453. doi:10.1001/archotol.1964.00750040462014
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