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October 1964

Neuroblastoma of Nodose Ganglion of Infant Vagus Nerve

Author Affiliations

Chief of Department of Plastic and Reconstructive Surgery of the Head and Neck, and Chief of Department of Otolaryngology, Mercy and Timken-Mercy Hospitals.

Arch Otolaryngol. 1964;80(4):454-459. doi:10.1001/archotol.1964.00750040466015

Introduction  Tumors of the vagus nerve are not common. Those of the cervical portions of the vagus nerve are extremely rare. A neuroblastoma of the cervical portion of the vagus nerve is practically unknown.This report presents the case of a proven neuroblastoma which, I believe, arose from the nodose ganglion of the left vagus nerve. The tumor apparently was present at birth, and removal was several months later.

Development of the Concept of the Neuroblastoma  An understanding of the developmental anatomy of neuroblastoma has been reviewed by Kincaid, Hodgson, and Dockerty in 1957,1 who pointed out that Virchow, in 1864, was the first to indicate these round cell tumors were not sarcomata but tumors of nerve origin. He labeled them gliomas. The same authors indicate that Marchand in 1891 reported that the round cells of what we now term "neuroblastomata," arose from the embryonic nerve system. Wright,2

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