Tumors of the central nervous system have been associated in many cases with alteration in the spinal fluid protein. It will be the purpose of this discussion to examine the changes which we found in the spinal fluid protein in this group of patients with acoustic neuromas.
Not all tumors of the brain have been associated with elevation in the protein content. Gliomas which have not extended to involve the ventricular wall or convexity surface are ofttimes associated with normal fluid. Likewise, pituitary tumors, when confined to the sella turcica, usually do not show significant alteration in the protein content. However, tumors in the posterior fossa except those that are deep in the cerebellar hemisphere or brain stem have been associated with a very high incidence of elevated protein.
It has been postulated that the elevation in the protein content is due to exudate from the tumor surface secondary to
HITSELBERGER WE, HOUSE WF. Cerebrospinal Fluid Protein Findings. Arch Otolaryngol. 1964;80(6):706–707. doi:10.1001/archotol.1964.00750040722013
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