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January 1965

Laryngeal Myoblastoma

Author Affiliations


Arch Otolaryngol. 1965;81(1):80-82. doi:10.1001/archotol.1965.00750050085018

Granular cell myoblastoma is considered a rare tumor. In 1926 Abrikossoff first described these tumors, presenting six cases, one a laryngeal tumor. He believed the lesions arose from degenerating primitive myoblasts after injury, and applied to them the name granular cell myoblastoma. Thirtythree cases have been reported, with my four cases bringing the total to 37.2-7

Granular cell myoblastoma has been reported to occur in the tongue, skin, breast, and subcutaneous tissues as well as the respiratory tract. The consensus today is that granular cell myoblastoma is a true neoplasm, although speculation persists concerning the histologic origin of the tumor. Striated muscle, histiocytes, fibroblasts, and peripheral nerves have all been suggested as tissues of origin.8

There have been no reports of malignant myoblastoma located in the respiratory tract. Although malignant varieties have been reported in other areas of the body,9 Azzopardi10 doubts the malignant nature of

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