THE SEARCH for basically different antibiotics has more or less ground to a standstill inasmuch as massive screening of antibiotic-producing organisms has yielded the same basic types of molecules repeatedly. Few new agents with clear clinical applicability are foreseen. On the other hand there is hope that synthetic molecules such as the nitrofurans and the semisynthetic penicillins may replace naturally occurring agents and permit us to develop drugs with "tailor-made" activity against certain of the more troublesome microorganisms. Meanwhile we will need to apply present drugs to best advantage. There must be careful use of drugs to prevent the emergence of new strains of resistant organisms and, where possible, employment of drug combinations where such are more effective than individual antibiotics.
Martin says that in "clean" operations an attempt at antimicrobial prophylaxis is potentially dangerous since it extends the time during which contamination can become infection. In patients with
SAUNDERS WH. Progress Report: Respiratory Infections and Antimicrobial Therapy. Arch Otolaryngol. 1965;81(3):315–318. doi:10.1001/archotol.1965.00750050324021
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