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April 1965

Cupulometry as an Investigative Tool

Author Affiliations

From the Department of Otolaryngology, New York University Medical School.

Arch Otolaryngol. 1965;81(4):340-346. doi:10.1001/archotol.1965.00750050351005

THE OBJECT of this study is to investigate the use of cupulometry in the clinical evaluation of drugs affecting the labyrinthine function.

Specifically, this report concerns a doubleblind study of the effects of the drug cinnarizine upon the reaction to rotational stimuli.

Cinnarizine is an antihistamine preparation of the piperazine group, structurally related to meclizine. Several investigators, among them Barrett and Zolov,1 Zolov,2 and Nelson and Stoesser,3 have studied the effects of this drug in various allergic conditions and conclude that it is an effective antihistaminic. Trumbull and co-workers4 in 1960 demonstrated that cinnarizine was able to prevent sea-sickness in a significant number of cases. More recently, Jongkees and Philipszoon5-8 investigated the effects of cinnarizine upon the labyrinthine function of experimental animals, patients with vertigo, and ten normal volunteers. It is upon this latter work that the present investigation is based.

Philipszoon tested the reaction