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June 1965

Homologous Lyophilized Vein: Experimental Study for Tympanic Closure in Dogs

Author Affiliations

From the departments of otolaryngology and pathology, Baylor University College of Medicine and Veterans Administration Hospital. Dr. Williams was formerly Fellow in Otology, Department of Otolaryngology, Baylor University College of Medicine; present address, Medical College of Virginia, Richmond.

Arch Otolaryngol. 1965;81(6):577-579. doi:10.1001/archotol.1965.00750050592009

AUTOGENOUS fresh vein used to repair a defect in the tympanic membrane provides a bridge for the epithelium.1 Furthermore, the vein contributes its own substance, particularly elastic fibers, to the repair of the tympanic membrane. The present study was undertaken to ascertain the possible role that homologous lyophilized vein may play in the surgical repair of tympanic defects.

Materials and Methods  Defects in the tympanic membranes in two dogs were closed with portions of lyophilized jugular vein from another dog. In one dog (A116-61) a defect made four weeks earlier had healed, so a new perforation, 0.4 X 0.6 cm, was made in the inferior part of the tympanic membrane. The defect was repaired by placing a segment of lyophilized vein beneath the opening on the inner surface of the membrane. The vein segment was held in place by absorbable-gelatin-sponge (Gelfoam) packing in the middle ear and the external

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