[Skip to Navigation]
July 1965

Oxyphilic Adenoma (Oncocytoma) of the Larynx: Presentation of a Case

Author Affiliations

From the Veterans Administration Center, Dayton, Chief, Ear, Nose and Throat Section.

Arch Otolaryngol. 1965;82(1):42-44. doi:10.1001/archotol.1965.00760010044010

OXYPHILIC adenomas are found principally in the parotid gland but also occur in various other sites. This tumor was first called oncocytoma,1 but the term oxyphilic adenoma, recommended later,2 has been generally accepted. The tumors are composed of solid, tubular, and glandular formations of large, irregular-shaped, oxyphilic, granular cells with small, vesicular, irregular, dark-staining nuclei-which have one or two moderately prominent nucleoli. These cells (oncocytes) were first described by Schaffer,3 and subsequently were also noted by Hamperl4; these authors found them principally in the parotid glands of older people. These cells also have been found in the bronchus,5 hard palate,6 nose and larynx,7 as well as in the pancreas, thyroid and parathyroid glands, and hypophysis.4 They are more commonly seen in women and are seldom seen in anyone less than 50 years of age.8 Stout believes that oxyphilic, granular cells found

Add or change institution