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August 1965

Biochemical Studies of Otosclerosis: II. Total Serum Alkaline Phosphatase

Author Affiliations

From the Otological Research Laboratories, Good Samaritan Hospital, director (Dr. Soifer), biochemist (Mr. Holdsworth); clinical professor of otolaryngology, Columbia University College of Physicians and Surgeons, New York (Dr. Altmann); assistant professor Department of Physiological Chemistry and Department of Surgery, Ohio State University, Columbus (Dr. Endahl).

Arch Otolaryngol. 1965;82(2):108-109. doi:10.1001/archotol.1965.00760010110008

Introduction  INCREASED alkaline phosphatase activity is associated with osteoblastic activity in new bone formation.1,2 It has not been established whether increased osteoblastic activity in otosclerosis is reflected in an alteration of the levels of serum alkaline phosphatase.Attempts to correlate serum calcium levels4-6 and serum alkaline phosphatase activity3 with otosclerosis have yielded conflicting results.3,7 Conflicting results as to whether otosclerotic bone contains high or low phosphatase activity also exist.8,9 In conflicting serum investigations, no mention was made to attempt to exclude subjects with liver and kidney abnormalities which might affect serum alkaline phosphatase levels.In a recent paper by our group,10 it was concluded that when normal and otosclerotic individuals were compared there was no difference in the electrophoretic mobility of serum alkaline phosphatase. No quantitative estimates of total enzyme activity were made, however, so the possibility of abnormal values in otosclerosis was

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