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September 1965

Sensorineural Deafness

Author Affiliations

From the Section of Otolaryngology of the University of Chicago.

Arch Otolaryngol. 1965;82(3):322-324. doi:10.1001/archotol.1965.00760010324024

A WIDE variety of clinical and experimental observations continues to increase our understanding of the pathogenesis, pathology, clinical course, and treatment of sensorineural deafness.

A method of acoustically stimulating the freshly removed isolated guinea pig cochlea and later histochemically examining fragments of end organ free of bony capsule is described by Vinnikov and Titova.1 Various histochemical tests before and after acoustic stimulation reveal functional significance of some enzymes and structural components in the various specialized cochlear cells. They claim that actetylcholine esterase, phosphorylase, alkaline and acid phosphatases, protein, sulfhydryl, disulfide bond, and carboxyl groups are found in the hairs of the hair cells of the organ of Corti but not in the hairs of the vestibular end organs. These hairs in the organ of Corti are compared to antennae, richly supplied with sensitive chemical substances possessing high energy-producing activity which reacts to the acetylcholine of the endolymph.

Spoendlin and

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