CALCULI in salivary ducts are known to evoke, in the course of time, metaplastic and proliferative changes in the ductal epithelium.1,2 Foote and Frazell1 deduced the possibility of a malignant neoplasm as a sequel of a long-standing irritation. A recently observed case apparently proves this point.
Report of Case
A 48-year-old woman was admitted to our department in August 1961 because of a painful submandiblar swelling of two weeks' duration. For the last 13 years she had been suffering from recurrent submandibular swelling, which increased during meals. Five years ago an x-ray examination revealed the presence of a stone in the right submandibular salivary gland. The patient refused an operation and was treated, during the acute episodes, by antibiotics.On examination the right submandibular salivary gland was found to be enlarged, firm, mobile, and tender to touch. The tissues of the floor of the mouth along the right
SHANON E, KESSLER E. Squamous Cell Carcinoma of Wharton's Duct: A Case of Long-Standing Calculus. Arch Otolaryngol. 1965;82(6):633–634. doi:10.1001/archotol.1965.00760010635015
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