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March 1966

Experimental Study of Bronchographic Media on Lung

Author Affiliations

From the departments of pathology and otolaryngology and the Cora and Webb Mading Department of Surgery, Baylor University College of Medicine, Houston.

Arch Otolaryngol. 1966;83(3):276-282. doi:10.1001/archotol.1966.00760020278019

BRONCHOGRAPHY is an important adjunct in the study of pulmonary diseases. Several bronchographic contrast media are available [eg, iodized oil (Lipiodol), aqueous propyliodone (Dionosil), oily propyliopydone and iopydol (Hytrast)], with each of the agents having certain advantages and disadvantages. This experimental study was done to evaluate lung-tissue reactions to bronchographic media using an unique experimental model—the excluded right upper lobe bronchus of the dog.

Methods  Twenty mongrel dogs, averaging 16 kg in weight, were divided into four groups of five dogs each. Following intravenous administration of barbiturate anesthesia, the right chest was entered through a fourth intercostal space incision. The right upper lobe bronchus was dissected free and divided. The proximal bronchial stump was closed and 2 ml of the contrast media were allowed to flow into the distal portion of the severed right upper lobe bronchus. One group received iodized oil, one group aqueous propyliodone, one group oily