This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor: The open letter of Dr. Mario Rius and Dr. Daoiz Mendoza is not very easy to understand. If I am right, the otosclerotic process starts, in the opinion of the authors, with a necrosis of the endochondral layer of the bony labyrinthine capsule. The diagnosis of "bone necrosis" is based on the disappearance of osteocytes in the lacunae and some specific chemical reactions.
It is a well-known fact that the ossification of the endochondral labyrinthine capsule is complete at the end of the second year of life. Normally no further bone formation takes place so that the endochondral layer consists throughout life of embryonic bone with an extremely low metabolism.
Also in the endochondral layer the rare osteocytes and the intercellular substances are an entity. If the osteocytes die, the intercellular substance is destined to be resorbed. Two forms of osteocyte death can be distinguished. During rapid
RIUS M, MENDOZA D. NEW HISTOLOGICAL OBSERVATIONS OF LABYRINTHINE CAPSULE IN RELATION TO THE ETIOLOGY OF OTOSCLEROSIS-Reply. Arch Otolaryngol. 1966;83(5):507–508. doi:10.1001/archotol.1966.00760020509034
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: