RADICAL NECK dissection appears to be the treatment of choice in thorium dioxide (Thorotrast) reaction, even when it is not possible to completely remove the mass of tissue involved. This belief is the result of our experience with a patient who presented with hoarseness and a large mass in the neck which proved by biopsy to be a thorium dioxide granuloma.
On reviewing the literature, the reported carcinogenic properties of thorium dioxide were revealed, as well as the fact that only two previous cases had been treated by radical neck dissection.
Our purpose, then, is to add a third case to the literature, review the properties of thorium dioxide, the complications resulting from its use (both symptomatic and carcinogenic), and to describe the patient's treatment by radical neck dissection performed nine years after the extravasation of thorium dioxide.
Evolution of Thorium Dioxide as a Diagnostic Agent
The radiographic contrast medium
CHALAT NI, ZANE AI. Radical Neck Dissection for Thorium Dioxide Granuloma: Case Report. Arch Otolaryngol. 1966;83(6):610–614. doi:10.1001/archotol.1966.00760020612026
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: