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August 1966


Author Affiliations

From the Department of Otolaryngology, Jefferson Medical College.

Arch Otolaryngol. 1966;84(2):234-237. doi:10.1001/archotol.1966.00760030236022

ELECTRON microscopy upon tissue obtained at the time of bronchoscopy demonstrated changes in the intercellular structure of the cell walls and membrane, particularly in patients with chronic bronchitis.1 The changes in bronchitis were those of degree only, and no absolute difference between normal bronchial mucosa and that of bronchitis could be demonstrated. Several observations were made on the bronchitic tissue, and the most marked was a great reduction in the amount of pellicular structure. Several other alterations of intercellular structure were less marked.

Experimentally, in dogs anticancer drugs introduced intrabronchially in the tumor zone were absorbed into the local blood and lymphatic circulations, reducing the possibility of drug toxicity that occurs from systemic administration.2 Since the high concentration in a cancer-containing bronchus may destroy fixed and free-floating malignant cells before, during, and after manipulation the use of chemotherapeutic agents through the bronchoscope may prove to be an adjunct

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