[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
September 1966

The Melkersson-Rosenthal Syndrome

Author Affiliations

From the Research and Educational Hospitals of the University of Illinois College of Medicine.

Arch Otolaryngol. 1966;84(3):292-296. doi:10.1001/archotol.1966.00760030294006

IN 1928, Melkersson1 wrote of a 35-year-old female patient afflicted with facial paralysis and facial edema. In 1931, Rosenthal2 described two families who displayed three cases of lingua plicata associated with the facial paralyses and facial edema. Prior to these descriptions, Hubschmann,3 in 1894, and Rossolimo,4 in 1901, reported syndromes of relapsing facial paralyses and facial edema, but the triad of seventh nerve palsy, facial edema, and lingua plicata was not attributed to Melkersson until Ekbom so declared it in his honor. Hubschmann did not note the tongue involvement, and Rossolimo augmented the triad to include migraine headaches.

The European literature contains abundant reports referable to the Melkersson-Rosenthal syndrome. In the British and American literature, such reports are sparse.

The purpose of this article is to arouse the reader to the existence of this entity, its prognostic implications, and its management.

In 1933, New and Kirch