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September 1966

Ciliostatic Effect of Phenol and Resorcinol

Author Affiliations

From the Institute of Hygiene, Karolinska Institutet and the Department of General Hygiene, National Institute of Public Health, Stockholm.

Arch Otolaryngol. 1966;84(3):325-328. doi:10.1001/archotol.1966.00760030327012

IN THE discussion concerning the cause of the ciliostatic effect of cigarette smoke, which has been demonstrated in a number of investigations, reference has naturally been made to several separate and chemically well-defined substances that are present in tobacco smoke. Since this smoke contains a great many different substances, several studies have simply distinguished between the gas phase and the particle phase in tobacco smoke. The gas phase refers to the fraction of the tobacco smoke that passes through an absolute filter, eg, a Cambridge filter, while the particle phase is the fraction of smoke that is caught by the filter. Most investigators agree that the ciliostatic effect is ascribable chiefly to the particle phase. However, the effect of individual substances on the ciliary beat has also been tested, eg, hydrogen cyanide, formaldehyde, phenol, etc. It is perhaps the last of these which has attracted the most attention.

Bernfeld and

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