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October 1966

Perilymph in Patients With Otosclerosis: Comparisons With Capillary Serum, Venous Serum, and Cerebrospinal Fluid

Author Affiliations

From the biochemical laboratory of the Department of Otorhinolaryngology, University of Würzburg, Germany.

Arch Otolaryngol. 1966;84(4):373-394. doi:10.1001/archotol.1966.00760030375002

CHEMICAL data on human perilymph obtained in vivo have seldom been published (Hladky et al,1 Wullstein et al,2 Ruedi et al,3 Schindler et al4).

A summary of the results hitherto recorded, with reference to the concentrations of the few substances examined, warrants the conclusion that perilymph is of an "extracellular" character, with a protein concentration considerably lower than in the serum, and probably higher than in the cerebrospinal fluid (CSF). It is the object of this paper to present a comprehensive summary of earlier findings, to discuss important sources of error for each microanalytical study, and to indicate some of the theoretical and clinical consequences.

Human perilymph is available only in very small quantities for isolated studies; the microanalytical techniques suitable for such studies are still very imperfect, so that the relative error considerably exceeds what would be bound up with studies using routine methods. If

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