BOYD'S textbook of surgical pathology1 describes osteogenic sarcoma as the most common, most malignant bone tumor. Generally speaking, this tumor is most common during the second decade of life, but it can appear at any age. It is rare after the age of 50 and is more often seen in men than women, with a ratio of about two to one. It is most commonly found at the ends of the shafts of long bones, the femur being the most likely bone to be involved, followed by the tibia and the humerus, respectively. Previous radiation and trauma may cause predisposition to this lesion, and it may develop in patients with Paget's disease of the bone. It metastasizes via the bloodstream with only occasional involvement of lymph nodes. The most common site for a metastatic lesion to occur is the lung. It rarely metastasizes to other bones, seldom invades the
HOFMANN WB. Osteogenic Sarcoma of the Mandible. Arch Otolaryngol. 1966;84(4):439–440. doi:10.1001/archotol.1966.00760030441014
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