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February 1967

Inner Ear Pathology in Acoustic Neurinoma

Author Affiliations

From the Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston. Dr. De Moura is presently at the Otological Research Laboratory, Henry Ford Hospital, Detroit, and is also affiliated with the Hospital dos Servidores do Estado in Rio de Janeiro.

Arch Otolaryngol. 1967;85(2):125-133. doi:10.1001/archotol.1967.00760040127002

ACOUSTIC neurinoma has been exhaustively studied clinically, anatomically, surgically, and pathologically. The most outstanding contributions appear to be those of Henschen (1915),1 Cushing(1917),2 Pool and Pava (1957),3 and recently House (1964).4 However, cases of acoustic neurinoma with clinical and histological reports are rare. In this communication the histological examinations of the temporal bones of ten patients with acoustic neurinomas are discussed correlating the pathological changes in the inner ear and the clinical symptomatology.

These tumors are benign, encapsulated, and arise as the result of neoplastic proliferation of Schwann's sheath cells of the eighth cranial nerve, usually from the vestibular division within the internal auditory meatus. This origin from Schwann's sheath cells was first suggested in 1908 by Verocay5 who expressed the opinion that the tumor arose from "nerve fiber cells" which he felt were capable of producing nerve fibers. The term "neurinoma," meaning nerve

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